Can zinc protect children from respiratory infections?

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Essays should explore observational and association studies in humans, evidence from randomised controlled trials, and pathophysiology and mechanistic studies to develop arguments.
Make sure you are using the most up-to-date evidence.
Regardless of the topic, you should begin your essay with an introduction, and finish with a summary and your final conclusions.
For each topic, some papers are listed for you to start with. You need to find a minimum of 5 more primary research articles (not reviews) to include in your critique of the evidence.

Describe the respiratory system and the role of the immune system in respiratory infection
Describe the role of zinc in the immune system
Use your critical skills to summarise the body of evidence for the use of zinc (diet or supplementation) to protect against respiratory infections in children

Use these references + 5 more
Maares and Haase. 2016. Zinc and immunity: An essential interrelation. Arch Biochem Biophys; 611:58-65. https://pubmed.ncbi.nlm.nih.gov/27021581/

Sempertegui et al. 2014. Zinc as an adjunct to the treatment of severe pneumonia in Ecuadorian children: a randomized controlled trial. Am J Clin Nutr; 99(3):497-505. https://pubmed.ncbi.nlm.nih.gov/24429536/

Suara and Crowe. 2004. Effect of zinc salts on respiratory syncytial virus replication. Antimicrob Agents Chemother; 48(3):783-90. https://pubmed.ncbi.nlm.nih.gov/14982765/

Eijkelkamp et al. 2019. Dietary zinc and the control of Streptococcus pneumoniae infection. PLOS Pathogens. doi.org/10.1371/journal.ppat.1007957 https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007957

Yuan et al. 2016. Effect of zinc supplementation on infants with severe pneumonia. World J Pediatr; 12(2):166-9. https://pubmed.ncbi.nlm.nih.gov/26684319/

Lassi et al. 2016. Zinc supplementation for the prevention of pneumonia in children aged 2 months to 59 months. Cochrane Database Sys Rev; 12 Art. No.: CD005978. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD005978.pub3/full

Howie et al. 2018. Zinc as an adjunct therapy in the management of severe pneumonia among Gambian children: randomized controlled trial. J Glob Health; 8(1):010418. https://pubmed.ncbi.nlm.nih.gov/29713463/

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